Therapeutic effects of methadone
and 1-alpha-acetylmethadol
by
Karp-Gelernter E, Wurmser L, Savage C
Am J Psychiatry 1976 Aug; 133(8):955-7

ABSTRACT

Many heroin addicts prefer methadone maintenance treatment to 1-alpha-acetylmethadol(LAAM) because of the "rush-like" effect of methadone. Although there have been no observable differences in the safety and effectiveness of the two drugs, LAAM appears to lead to a more stable, consistent physiological state. The authors report on two patients who had ego defects characterized by severe mood swings. Both patients preferred LAAM to methadone because of its stabilizing effect and smoother action.

Pain
LAAM
Fentanyl
Tramadol
Methadone
Endomorphins
Intravenous rush
LAAM v methadone
Methadone and heroin
Methadone and cocaine
Opioids and depression
Buprenorphine v methadone
Methadone maintenance/subliminal euphoria
Methadone: pharmacokinetics/pharmacodynamics

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